Alessio’s work focuses on sensors based on red fluorescent proteins. To overcome the limitations associated with these, he aspires to make red-shifted genetically encoded tools to study neurochemical communication widely available. He is also using self-labeling proteins (HaloTag, SNAP-tag) to build new chemogenetic indicators to complement the use of fluorescent proteins for sensor design. Alessio holds a PhD in Biochemistry and Biophysics from Leiden University in the Netherlands. He then worked on DNA nanotechnology at Arizona State University and optical tools development at NIH/NHLBI before joining the Tian Lab.